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Biochemistry

This tiny sensor, TRPA1, may be found anywhere in the skin or epithelium lining the mouth, nose and throat. It’s sensitive to an array of chemical irritants including tear gas and wasabi. Credit: Yang Suo, ��ţӰ��

December 19, 2019

Cryo-Electron Microscope Captures Details of the ‘Wasabi Sensor’

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photo of a phage virus trapped by its prey

November 14, 2019

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November 4, 2019

Duke Flags Lowered: Biochemist Irwin Fridovich Dies at Age 90

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We Need More Doctors Who Are Scientists

September 24, 2019

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Eric Oberstein of Duke Performances won his second Grammy in February. Photo by Justin Cook.

September 16, 2019

High Honors

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Unless they’ve had a family member with cancer, most people don’t know that cancer cells mutate rapidly to escape the drugs we use to kill them.

February 22, 2019

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An ion channel in human nerve cells called the transient receptor potential melastatin member 8 (TRPM8) senses both coldness and menthol, transmitting cooling sensations by releasing calcium (green spheres). Image: Ying Yin

February 7, 2019

Defining the Shape of Cool

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Epigenetics involves modifications to DNA that do not change its sequence but only affect which genes are active, or expressed. Photo courtesy of whatisepigenetics.com

January 30, 2019

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Just as squeezing the top of a balloon changes its overall shape, the interaction of hormones and drugs in the bloodstream changes the shape of cell surface receptors. Mapping the shapes in detail gives researchers hope of developing more better drugs.

January 10, 2019

Seeing Shapeshifting Receptors at Work Could Yield New Drugs

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Jane Richardson

October 23, 2018

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Robert Webster and Paul Modrich

October 5, 2018

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Hashim Al-Hashimi

July 18, 2018

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In a 3D illustration, a blue molecule is bound to a purple RNA molecule

May 4, 2018

Molecular Movies of RNA Guide Drug Discovery

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DNA bases can shape-shift for a thousandth of a second, briefly morphing into alternative states that allow for mismatches as the molecule is copied. These spelling errors can drive evolution and disease.

January 31, 2018

A Mutational Timer is Built Into the Chemistry of DNA

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Robert Lefkowitz was famous for his mentoring long before he shared a Nobel Prize with a mentee. (Duke Photo)

November 9, 2017

An Interview with Bob Lefkowitz, Five Years After His Nobel

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This scanning electron micrograph shows a mouse immune cell (yellow) infected with Francisella tularensis bacteria (blue). Credit: National Institute of Allergy and Infectious Disease.

September 6, 2017

Molecular Map Shows How to Disable Dangerous Bioweapon

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